ServerName yourdomain.com DocumentRoot /opt/flask-app/ WSGIDaemonProcess app user=www-data group=www-data threads=5 python-home=/opt/flask-app/flask-venv WSGIScriptAlias / /opt/flask-app/flask-app.wsgi ErrorLog ${APACHE_LOG_DIR}/flask-error.log CustomLog ${APACHE_LOG_DIR}/flask-access.log combined WSGIProcessGroup app WSGIApplicationGroup %{GLOBAL} Order deny,allow Require all granted